Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports.

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins. Now a ...

Epigenetic silencing governs key biological processes, from flowering time in plants to preventing uncontrolled cell growth ...

He and several colleagues recently published an article in the journal "Molecular Biology and Evolution" about how cells manage extra copies of genes, known as daughter copies. Genes act as a sort of ...

CAST systems aren’t found in humans, and when used in human cell cultures they produce a successful DNA insertion only 0.1% of the time—far too low for gene therapy purposes.

The processes that keep a cell alive are constantly challenged by unpredictable changes in its environment. Cells manage to counteract these changes by employing sophisticated regulatory strategies ...

A new predictive AI system has been developed to predict gene activity in human cells with high precision.

“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...