"Because many biological conclusions rely on the presumption that synonymous mutations are neutral, its invalidation has broad implications." When researchers are investigating disease, for example, ...

Point mutations that alter the resulting protein sequences are called nonsynonymous mutations, while those that do not alter protein sequences are called silent or synonymous mutations.

Researchers are adding new evidence to the emerging concept that 'silent' or synonymous mutations may have crucial consequences. Their study showed how a synonymous mutation in one gene ...

Changes in the genetic sequence have long been thought to be relatively benign when they are synonymous, or silent; this means that there are changes in the normal genetic sequence, but the same amino ...

Point mutations that alter the resulting protein sequences are called nonsynonymous mutations, while those that do not alter protein sequences are called silent or synonymous mutations.

A central assumption about so-called synonymous mutations, which are changes in the coding sequence of proteins that do not lead to changes in its amino acid sequence, is being questioned by a study ...

The frame-shift mutation (c.1691_1693delinsG) of SCNN1B gene was identified by whole-exome sequencing and Sanger sequencing in a family with hypertension.

Some 250 different mutations have so far been screened in the cystic fibrosis (CF) gene. The 50 nonsense, 33 splicing and 60 frameshift mutations are randomly distributed within the gene, unlike ...

A team of scientists from Australia has recently identified a frameshift deletion mutation in ORF7a of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).