Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by ...

Homologous recombination (HR) is a ubiquitous genetic phenomenon, essential when environmental and internal stressors cause DNA damage, which can lead to breakages in both strands of double-stranded ...

DNA damage repair (DDR) deficiency in the setting of endogenous and exogenous DNA damaging events is a key hallmark of cancer and an actionable therapeutic vulnerability. 1 Homologous recombination ...

In contrast, homologous recombination (HR) is a more accurate form of DNA repair—but it occurs infrequently, making precision editing difficult.

In the latter situation, DSBs are intentionally introduced to allow genetic recombination by mixing parental genes. Homologous recombination—a crucial meiotic event—not only enhances genetic ...

Tumors with compromised ability to repair double-strand DNA breaks by homologous recombination, including those with defects in BRCA1 and BRCA2, are highly sensitive to blockade of the repair of DNA ...

Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The ...

Cells use homologous recombination to stitch double-stranded breaks (DSB) back together and the enzyme telomerase to cap exposed ends of a DNA strand with a repetitive DNA sequence called a telomere.

About half of high-grade serous ovarian cancers have homologous recombination deficiency, but the fraction of endometrial cancers that are homologous recombination deficient is probably much lower.