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Play the USA TODAY Quick Cross now. What is the strongest anti-inflammatory medication? Naproxen is considered to be the strongest anti-inflammatory medication available over the counter, says Walia.

A new NIH study has found an increased risk for cardiovascular problems in patients taking the painkiller naproxen, sold over-the-counter by Bayer under the Aleve brand name.

What is the strongest anti-inflammatory medication? Naproxen is considered to be the strongest anti-inflammatory medication available over the counter, says Walia.

Naproxen use did not confer a protective effect; rather it increased risk by 18% (p=0.01)." The analysis also showed that indomethacin and possibly diclofenac increased the risk of AMI and SCD.

In this prospective cohort study, the researchers used a nested case-control analysis to evaluate the association between the chronic use of NSAIDs and the risk of myocardial infarction.