Background: While the incidence of sudden death in athletes is low, a number of clinically unsuspected cardiovascular diseases have been linked to sudden death in young well-trained athletes.

Risk prediction has been used in the primary prevention of cardiovascular disease for >3 decades. Contemporary cardiovascular risk assessment relies on multivariable models, which integrate ...

Clonal hematopoiesis (CH), the benign clonal expansion of hematopoietic stem cells, is often caused by somatic sequence variations in genes associated with hematologic malignancies. Over the past ...

There is an emerging convergence between atherosclerotic cardiovascular disease and cancer, driven by shared risk factors and overlapping pathophysiologic mechanisms. Traditional factors, such as ...

BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...

Premenopausal women presenting with acute coronary syndrome (ACS) are a unique and often underrecognized patient population. Although they are traditionally considered at lower cardiovascular risk ...

A 68-year-old man without previous comorbidities presented to the emergency department with complaints of palpitations and giddiness. On examination, his pulse rate was 92 beats per minute, and his ...

In January 2026, Circulation: Cardiovascular Quality and Outcomes changed its name to Circulation: Population Health and Outcomes. The goal of Circulation: Population Health and Outcomes is to ...

Introduction: Hypertension, a key driver of global cardiovascular diseases, has prompted interest in nutritional solutions like dietary supplements for managing blood pressure. The flavonoid quercetin ...

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Background: Patients with intermediate-high risk pulmonary embolism (PE) have an elevated right-to-left-ventricular (RV/LV) diameter ratio and are at risk of early clinical decompensation and ...

Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an under-diagnosed and life-threatening progressive infiltrative cardiomyopathy characterized by the abnormal deposition of misfolded ...